Modern opportunities and problematic aspects of diagnostics and treatment of patients with neuroendocrine tumors

Objective. To study modern diagnostic capabilities and identify available ways to improve the results of treatment patients with NET digestive organs. Neuroendocrine tumors (NET) are neoplasms difficult diagnose treat, which localized mainly in tract.
 Materials methods. The observation 325 were studied: gastrointestinal tract 189 (58.1 %) persons, pancreas 125 (38.5 %), without established localization 11 (3.4 %). various malignancy prevailed 92.3 %. Laboratory diagnostics included tumor markers (CGA, serotonin, 5-HIAA, etc.), instrumental endoscopic (FGS, FCS), radiation (US, CT, MRI), radioisotope (PET-CT 18-FDG, 68-Ga-peptides) morphological (histology, immunohistochemistry) research.
 Results. Nonspecific symptoms noted 3848 % patients, asymptomatic course 2025 sensitivity CGA was 54 %, serotonin 5- HIAA depended on presence carcinoid syndrome prevalence tumor. Multiphase CT is main method diagnosis small intestinal NET, allows you differentiate pancreatic by degree malignancy. surgical intervention provides best non-metastatic but case generalized tumors, its combination antitumor therapy prolongs duration life 2 times.
 Conclusions. Personalized therapeutic tactics, taking into account clinical features ensures optimal detection treatment, improves survival quality among patients.